Diabetes risk gene ‘from Neanderthals’

by PAUL RINCON

Neanderthals interbred with humans and their genes are scattered among us today

A gene variant that seems to increase the risk of diabetes in Latin Americans appears to have been inherited from Neanderthals, a study suggests.

We now know that modern humans interbred with a population of Neanderthals shortly after leaving Africa 60,000-70,000 years ago.

This means that Neanderthal genes are now scattered across the genomes of all non-Africans living today.

Details of the study appear in the journal Nature.

The gene variant was detected in a large genome-wide association study (GWAS) of more than 8,000 Mexicans and other Latin Americans. The GWAS approach looks at many genes in different individuals, to see whether they are linked with a particular trait.

People who carry the higher risk version of the gene are 25% more likely to have diabetes than those who do not, and people who inherited copies from both parents are 50% more likely to have diabetes.

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