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In mice without the key enzyme, fatty acid synthase, bad bacteria invade the colon and the small intestine, which creates the inflammation underlying insulin resistance and diabetes. In the mouse colon above, a protein (shown in red) that makes up the protective membrane in the gut is not functioning properly. Credit: Washington University School of Medicine
Scientists at Washington University School of Medicine in St. Louis have made a surprising discovery about the origin of diabetes. Their research suggests that problems controlling blood sugar — the hallmark of diabetes — may begin in the intestines.
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